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Which team is going to come out on top on Monday, Oct. 12, when the Los Angeles Rams and Buffalo Bills go head to head at 8:15 p.m. ET? Our computer projection sides with the Rams. Check out our other projections below, where we break down the final score, spread, and over/under.
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Bills vs. Rams Game Info and TV Channel
- When: Monday, October 12, 2026 at 8:15 p.m. ET
- Where: SoFi Stadium in Inglewood, California
- TV: ABC/ESPN
- Live Stream: Watch this game on Fubo (Regional restrictions may apply)
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Listen to the game on 93.1 Jack FM
Bills vs. Rams Odds and Betting Info
- Spread favorite: Rams (-3.5)
- Moneyline: Rams (-178), Bills (+149)
- Total: 54.5 points
Bills vs. Rams Prediction
- Pick ATS: Rams (-3.5)
- Pick OU: Under (54.5)
Prediction:
Rams 30 - Bills 20
Prediction derived from a team strength comparison algorithm. Multiple factors such as strength of wins and scoring margin are used to make this projection.
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Bills vs. Rams Betting Insights
- The Rams have covered twice in four chances against the spread this season.
- The Bills have put together a 3-1-0 record against the spread this season.
- Los Angeles has covered the spread twice when favored by 3.5 points or more this season (in three opportunities).
- So far this season, two Rams games have hit the over.
- In 2026, three Bills games have hit the over.
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