Photo: Ronald Martinez / Getty Images Sport / Getty Images
When the Los Angeles Rams play the San Francisco 49ers at 4:25 p.m. ET on Sunday, Nov. 9, our projection system predicts the Rams will come out on top. Our model also projects the spead, point total, and final score, which you can see below.
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Rams vs. 49ers Game Info and TV Channel
- When: Sunday, November 9, 2025 at 4:25 p.m. ET
- Where: Levi's Stadium in Santa Clara, California
- TV: FOX
- Live Stream: Watch this game on Fubo (Regional restrictions may apply)
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Listen to the game on 107.7 The Bone
Rams vs. 49ers Odds and Betting Info
- Spread favorite: Rams (-5.5)
- Moneyline: Rams (-259), 49ers (+210)
- Total: 49.5 points
Rams vs. 49ers Prediction
- Pick ATS: 49ers (+5.5)
- Pick OU: Under (49.5)
Prediction:
Rams 23 - 49ers 19
Prediction derived from a team strength comparison algorithm. Multiple factors such as strength of wins and scoring margin are used to make this projection.
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Rams vs. 49ers Betting Insights
- The Rams have compiled a 6-2-0 ATS record so far this year.
- The 49ers are 5-4-0 ATS this year.
- Los Angeles is 6-1 ATS this season when playing as at least 5.5-point favorites.
- When playing as at least 5.5-point underdogs this season, San Francisco has an ATS record of 4-2.
- The Rams and their opponent have combined to go over the point total three out of eight times this season.
- The 49ers and their opponent have combined to hit the over five out of nine times this year.
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