Photo: Carmen Mandato / Getty Images Sport / Getty Images
Based on our computer model, the Indianapolis Colts will defeat the Los Angeles Chargers when the two teams come together at SoFi Stadium on Sunday, Oct. 19, which begins at 4:05 p.m. ET. For our predictions on the spead, point total, and final score, check out the rest of the article below.
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Chargers vs. Colts Game Info and TV Channel
- When: Sunday, October 19, 2025 at 4:05 p.m. ET
- Where: SoFi Stadium in Inglewood, California
- TV: CBS
- Live Stream: Watch this game on Fubo (Regional restrictions may apply)
- Live Stream: Watch this game on Paramount+ (Regional restrictions may apply)
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Listen to the game on ALT 98.7
Chargers vs. Colts Odds and Betting Info
- Spread favorite: Chargers (-2.5)
- Moneyline: Chargers (-140), Colts (+117)
- Total: 48.5 points
Chargers vs. Colts Prediction
- Pick ATS: Colts (+2.5)
- Pick OU: Under (48.5)
Prediction:
Colts 27 - Chargers 20
Prediction derived from a team strength comparison algorithm. Multiple factors such as strength of wins and scoring margin are used to make this projection.
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Chargers vs. Colts Betting Insights
- The Chargers are 3-3-0 ATS this season.
- The Colts have compiled a 4-2-0 record against the spread this year.
- Los Angeles has covered the spread once this season (1-3 ATS) when playing as at least 2.5-point favorites.
- Chargers games have hit the over twice this season.
- So far this season, three out of the Colts' six games with a set over/under have hit the over.
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