Big Ten foes match up when the USC Trojans (4-1) and the No. 15 Michigan Wolverines (4-1) play on Saturday, October 11, 2025 at Los Angeles Memorial Coliseum.
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USC vs. Michigan Matchup Info
- Game date: Saturday, October 11, 2025
- Game time: 7:30 p.m. ET
- Location: Los Angeles, California
- Venue: Los Angeles Memorial Coliseum
- TV channel: NBC
- Live Stream: Watch this game on Fubo (Regional restrictions may apply)
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USC vs. Michigan Odds and Prediction
- Spread favorite: Trojans (-2.5)
- Moneyline: Trojans (-143), Wolverines (+120)
- Total: 56.5 points
- Pick ATS: Michigan (+2.5)
- Pick OU: Over (56.5)
- Prediction: USC 31, Michigan 29
Prediction derived from a team strength comparison algorithm. Multiple factors such as strength of wins and scoring margin are used to make this projection.
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USC vs. Michigan Betting Records and Insights
- USC has won two games against the spread this season.
- Michigan has won two games against the spread this year.
- The Trojans have covered the spread twice this season (2-3 ATS) when playing as at least 2.5-point favorites.
- The Wolverines have not covered the spread this season (0-1 ATS) when playing as at least 2.5-point underdogs.
- USC games have hit the over four out of five times this season.
- So far this season, three of Michigan's five games with a set number have hit the over.