The Los Angeles Rams should come out on top in their matchup versus the San Francisco 49ers at 8:15 p.m. ET on Thursday, Oct. 2, according to our computer projections. If you're seeking more projections on the final score, spread, and point total, we've got you covered below.
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Rams vs. 49ers Game Info and TV Channel
- When: Thursday, October 2, 2025 at 8:15 p.m. ET
- Where: SoFi Stadium in Inglewood, California
- TV: Amazon Prime Video
- Live Stream: Watch this game on Fubo (Regional restrictions may apply)
- Live Stream: Watch this game on Prime Video (Regional restrictions may apply)
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Listen to the game on 93.1 Jack FM
Rams vs. 49ers Odds and Betting Info
- Spread favorite: Rams (-8.5)
- Moneyline: Rams (-463), 49ers (+356)
- Total: 43.5 points
Rams vs. 49ers Prediction
- Pick ATS: 49ers (+8.5)
- Pick OU: Under (43.5)
Prediction:
Rams 23 - 49ers 19
Prediction derived from a team strength comparison algorithm. Multiple factors such as strength of wins and scoring margin are used to make this projection.
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Rams vs. 49ers Betting Insights
- The Rams have put together a 3-1-0 record against the spread this season.
- The 49ers have covered twice in four chances against the spread this year.
- Rams games have hit the over twice this season.
- This season, games featuring the 49ers have gone over the point total twice.
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