The No. 25 USC Trojans (3-0) square off against a fellow Big Ten foe when they host the Michigan State Spartans (3-0) on Saturday, September 20, 2025 at Los Angeles Memorial Coliseum.
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USC vs. Michigan State Matchup Info
- Game date: Saturday, September 20, 2025
- Game time: 11 p.m. ET
- Location: Los Angeles, California
- Venue: Los Angeles Memorial Coliseum
- TV channel: FOX
- Live Stream: Watch this game on Fubo (Regional restrictions may apply)
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USC vs. Michigan State Odds and Prediction
- Spread favorite: Trojans (-18.5)
- Moneyline: Trojans (-1010), Spartans (+646)
- Total: 55.5 points
- Pick ATS: Michigan State (+18.5)
- Pick OU: Over (55.5)
- Prediction: USC 38, Michigan State 26
Prediction derived from a team strength comparison algorithm. Multiple factors such as strength of wins and scoring margin are used to make this projection.
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USC vs. Michigan State Betting Records and Insights
- USC has won two games against the spread this season.
- Michigan State is winless against the spread this year (0-3-0).
- The Trojans have covered the spread twice when favored by 18.5 points or more this season (in three opportunities).
- USC games have gone over the point total twice this season.
- This year, games featuring Michigan State have hit the over twice.